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Erythema multiforme (a multi-shaped red rash) is characterized by target-like lesions, which often look for all the world like a bull's eye with a raised dot in the middle, surrounded by one or two rings. The rash is generally located on the arms and legs. While it appears somewhat like urticaria (hives), it is not itchy. Erythema multiforme is often a recurrent, postinfectious process, frequently associated with herpes simplex virus and mycoplasma infections. It is a self-limited condition, and rarely causes any major problems. Erythema multiforme is often confused with giant urticaria, another harmless condition, or Stevens-Johnson syndrome, which can be quite serious.