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A fistula (FIST-you-lah) is an abnormal connection between two internal cavities in the body, or a tract that leads from a hollow organ such as the intestine to the skin surface. These may arise as a result of perianal abscess, Crohn's disease, appendicitis, or a host of other causes. The most dangerous and dramatic of fistulas is the congenital tracheoesophageal fistula.